Scaffold-mediated delivery for non-viral mRNA vaccines
نویسندگان
چکیده
منابع مشابه
mRNA delivery using non-viral PCL nanoparticles.
Messenger RNA (mRNA) provides a promising alternative to plasmid DNA as a genetic material for delivery in non-viral gene therapy strategies. However, it is difficult to introduce mRNA in vivo mainly because of the instability of mRNA under physiological conditions. Here, mRNA-protamine complex encapsulated poly(ε-caprolactone) (PCL) nanoparticles (NPs) are proposed for the intracellular delive...
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Glial cell line-derived neurotrophic factor (GDNF) supports the growth and survival of dopaminergic neurons. CNS gene delivery currently relies on invasive intracerebral injection to transit the blood-brain barrier. Non-viral gene delivery via systematic transvascular route is an attractive alternative because it is non-invasive, but a high-yield and targeted gene-expressed method is still lack...
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Chapter 1 describes the barriers that have hindered the effective use of gene delivery and a literature review of methods designed to overcome those barriers. Areas of gene delivery that will be discussed include viral, physical, and non-viral methods of gene delivery. A special focus will be on methods to target gene delivery vehicles and more specifically the somatostatin receptor 2 (SSTR2) t...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2018
ISSN: 0969-7128,1476-5462
DOI: 10.1038/s41434-018-0040-9